Assignment First

加拿大代写被抓:玻尔效应与氧亲和力

质子结合中氧结合的变化

减少了玻尔效应

在Hb中促进玻尔效应的BetaHis46与血红蛋白Bassett r状态中的betaAsn139相互作用

玻尔效应的40%来自t状态HbA(血红蛋白A)中His146和Asp94之间的盐桥

质子化的betaHis146 N原子降低玻尔效应

加拿大代写被抓:玻尔效应与氧亲和力

降低氧亲和力

二聚体间斥力的消除。

在r态接触点上任何氢键的破坏都会显著降低氧的亲和力

去除alpha1Asp94和beta2Asn102之间的相互作用会降低血红蛋白的氧稳定性,从而降低氧亲和力。

加拿大代写被抓:玻尔效应与氧亲和力

oxygenation-linked changes in proton binding
Reduced Bohr Effect
BetaHis46 which contribute to Bohr Effect in Hb interacts with betaAsn139 in R-state of hemoglobin Bassett
40% of the Bohr Effect comes from salt-bridges between His146 and Asp94 in T-state HbA (Hemoglobin A)
Protonation of betaHis146 N atom lowers the Bohr Effect

加拿大代写被抓:玻尔效应与氧亲和力

Lowered oxygen affinity
Removal of the interdimer repulsion .
Disruption of any H-bond at the contact point in R-state lowers the oxygen affinity significantly
Removal of interaction between alpha1Asp94 and beta2Asn102 reduces oxyhemoglobin stability, thus decreasing oxygen affinity。