Assignment First

数学作业代写:血红蛋白的R和T状态与临床效果

平衡变为t态。

氧合的r态比t态更不稳定

与HbA相比,处于r态的Hb – Bassett的氢键更少,而处于t态的Hb – Bassett的氢键更少。

三种新的r态h键的形成赋予了Hb Bassett的t态性质。

数学作业代写:血红蛋白的R和T状态与临床效果

这种突变体不能很好地结合氧气,为组织提供氧气

低血氧饱和度

低p50(用于降低酶活性50%,与氧饱和度有关)

间歇性发绀、贫血的临床疗效

血红蛋白稳定性降低。

数学作业代写:血红蛋白的R和T状态与临床效果

Equilibrium shifts to T-state .
More destabilization of oxygenated R-state compared to T-state
Hb Bassett in R-state has less hydrogen bond compared to HbA, compared to T-state。
The formation of three new H-bonds in R-state gives Hb Bassett T-state properties。

数学作业代写:血红蛋白的R和T状态与临床效果

The mutant variant is not able to bind oxygen well enough to supply oxygen to tissues
Low oxygen saturation
Low p50 (Used to lower the enzyme activity by 50%which is related to the saturation of oxygen)
Clinical outcome of episodic cyanosis and anemia
Reduced hemoglobin stability .