数学作业代写：血红蛋白的R和T状态与临床效果
平衡变为t态。
氧合的r态比t态更不稳定
与HbA相比，处于r态的Hb – Bassett的氢键更少，而处于t态的Hb – Bassett的氢键更少。
三种新的r态h键的形成赋予了Hb Bassett的t态性质。
数学作业代写：血红蛋白的R和T状态与临床效果
这种突变体不能很好地结合氧气，为组织提供氧气
低血氧饱和度
低p50(用于降低酶活性50%，与氧饱和度有关)
间歇性发绀、贫血的临床疗效
血红蛋白稳定性降低。
数学作业代写：血红蛋白的R和T状态与临床效果
Equilibrium shifts to T-state .
More destabilization of oxygenated R-state compared to T-state
Hb Bassett in R-state has less hydrogen bond compared to HbA, compared to T-state。
The formation of three new H-bonds in R-state gives Hb Bassett T-state properties。
数学作业代写：血红蛋白的R和T状态与临床效果
The mutant variant is not able to bind oxygen well enough to supply oxygen to tissues
Low oxygen saturation
Low p50 (Used to lower the enzyme activity by 50%which is related to the saturation of oxygen)
Clinical outcome of episodic cyanosis and anemia
Reduced hemoglobin stability .